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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP29 decreases the amount of TNF. 2 / 2

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"Interestingly, we found that knockdown of USP29 significantly impaired various cytoplasmic DNA induced expression of IFNB, TNF, and IP10 but had little effect on cGAMP induced expression of IFNB, TNF, and IP10."

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"Knockdown of USP29 by these two shRNAs significantly inhibited HSV-1-induced expression of IFNB, TNF, IL6, and IP10 in THP-1 cells (The # 2 shRNA was used for the following experiments and similar results were observed with # 1 shRNA)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...