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USP18 activates TCR. 1 / 1

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"Because USP18 deficiency potentiated activation of molecules such as IKK, JNK, and NFAT distal from TCR, but not TCR proximal signaling complex ZAP70 or PLC-gamma, we reasoned that USP18 might target some key molecules in between the proximal and distal signaling complexes, of which TAK1 is a promising candidate."

23825189

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Colored badges next to statement headings correspond to evidence counts from knowledge sources, as shown below. Badges to the left of the | separator correspond to curated knowledge base sources, and badges to the right of it correspond to machine reading systems.

IndraLab

Statements

USP18 activates TCR. 1 / 1

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