IndraLab

Statements

Doxazosin inhibits KCNH2. 10 / 11
1 | 9
reach
"The antihypertensive agent, doxazosin pharmacologically blocks the hERG channel [XREF_BIBR]."
18948620
reach
"An unexpected finding was revealed : simultaneous application of 100 microM terazosin attenuated doxazosin induced hERG suppression to 24.5 +/-11.4% (n = 3; p = 0.07; XREF_FIG)."
24516604
reach
"The hERG blocker doxazosin has been proven as a proapoptotic agent in a wide range of in vitro and in vivo studies."
21850047
tas
No evidence text available
21185626
reach
"Furthermore, additional reduction of hERG viability in the presence of anti-HERG siRNA may be caused by doxazosin induced suppression of residual hERG protein (~ 42%)."
24516604
reach
"XREF_BIBR reported that doxazosin can directly block KCNH2, and the sensitivity is influenced by the mutation of KCNH2 (1956, C> T), while other research found that celiprolol involved in modulating the function of endothelial cells and had certain antioxidant stress effects XREF_BIBR, XREF_BIBR."
23613831
reach
"Given that GB cells express hERG channels and that hERG suppression by doxazosin induces apoptosis, we hypothesized that pharmacological targeting of hERG channels would induce apoptosis of GB cells."
24516604
reach
"Finally, antagonism of doxazosin induced hERG protein suppression and glioblastoma cell death by co-treatment of terazosin and doxazosin indicates the functional relevance of hERG protein in GB cell apoptosis."
24516604
reach
"29 In addition, hERG blockers doxazosin and terazosin did not cause cell cycle arrest despite hERG expression in distinct cell lines, for example, LNCaP prostate carcinoma cells."
21850047
reach
"In conclusion, this study demonstrates that HERG potassium channels are blocked by prazosin, doxazosin, and terazosin."
15098086