IndraLab

Statements

USP15 is phosphorylated on S678. 5 / 5
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"These results clearly indicate that USP15 Ser678 phosphorylation is required for its function in HR."
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"USP15 is phosphorylated at Ser678 and recruited to DSBs."
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"We confirmed that USP15 S678 phosphorylation is essential for its functions in HR and genome stability."
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"As shown in Fig.  xref , mutation at Ser678 abolished ATM-dependent USP15 phosphorylation, indicating that Ser678 is the major ATM phosphorylation site of USP15."
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"Mechanistically, USP15 is recruited to DNA double-strand breaks (DSBs) by MDC1, which requires the FHA domain of MDC1 and phosphorylated Ser678 of USP15."
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