IndraLab

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USP7 activates DNA repair. 3 / 3
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"Additionally, in a series of in vitro bladder cancer cells we have investigated whether the pharmacological inhibition of USP7, by lowering the levels of CCDC6, was able to impair the DNA repair processes by homologous recombination (HR), favouring the bladder cancer cells sensitivity to PARP-inhibitors."
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"Pharmacological inhibition of USP7 controls CCDC6 stability and impairs the DSBs DNA repair in prostate cancer cells."
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"Accordingly, an siRNA knockdown of USP7 should lead to a reduced amount of BER enzymes and impair DNA repair."
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