IndraLab

Statements

USP7 activates DNA repair. 5 / 5
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"Additionally, in a series of in vitro bladder cancer cells we have investigated whether the pharmacological inhibition of USP7, by lowering the levels of CCDC6, was able to impair the DNA repair processes by homologous recombination (HR), favouring the bladder cancer cells sensitivity to PARP-inhibitors."
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"Among the USPs, special attention is given to the USP7 enzyme, whose over-expression contributes to several human malignancies by promoting cell proliferation and DNA repair and by inhibiting apoptosis [6,7]."
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"Loss or inhibition of USP7 has also been shown to partially disrupt DNA repair by homologous recombination, leading to significant tumor cell death, independently of ATM and p53, through the accumulation of genotoxic levels of DNA damage [37]."
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"Pharmacological inhibition of USP7 controls CCDC6 stability and impairs the DSBs DNA repair in prostate cancer cells."
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"Accordingly, an siRNA knockdown of USP7 should lead to a reduced amount of BER enzymes and impair DNA repair."
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