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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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USP7 activates DNA repair. 3 / 3

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"Additionally, in a series of in vitro bladder cancer cells we have investigated whether the pharmacological inhibition of USP7, by lowering the levels of CCDC6, was able to impair the DNA repair processes by homologous recombination (HR), favouring the bladder cancer cells sensitivity to PARP-inhibitors."

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"Pharmacological inhibition of USP7 controls CCDC6 stability and impairs the DSBs DNA repair in prostate cancer cells."

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"Accordingly, an siRNA knockdown of USP7 should lead to a reduced amount of BER enzymes and impair DNA repair."

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USP7 activates DNA repair. 3 / 3

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