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USP8 leads to the deubiquitination of F2RL1. 2 / 2

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"Expression of the catalytically inactive mutants, AMSH(D348A) and UBPY(C786S), caused an increase in PAR(2) ubiquitination and trapped the receptor in early endosomes, thereby preventing lysosomal trafficking and degradation."

19684015

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"USP8 and AMSH mediate deubiquitination of PAR2 and its sorting from endosomes to lysosomes [XREF_BIBR]."

28448471

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IndraLab

Statements

USP8 leads to the deubiquitination of F2RL1. 2 / 2

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