IndraLab

Statements

PABPC1 activates PAN2. 3 / 3
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"Because Pab1 stimulates Pan2 and interacts directly with Pan3 through its C-terminal region, an alternative interpretation could be that removal of the corresponding Pab1 domain inhibits deadenylation by preventing Pan2 action."
17766253
sparser
"Pab1 can recruit or activate the deadenylases Pan2-Pan3 and the Ccr4 subunit of the Ccr4-Not complex, which cooperate in shortening the pA tail, thought to be a prerequisite for degradation of the transcript ( xref , xref )."
38903079
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"Since Pab1 promotes Pan2 activity, one model is that this deadenylation reflects Pab1 bound to the first ~ 65 residues of the A tail, but the 3 ' most region is exposed and thereby rapidly deadenylated by Pan2."
22785621