IndraLab

Statements

USP15 inhibits NFATC2. 3 / 4
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"Ubiquitin-specific peptidase 15 (USP15) can stabilize MDM2, as well as degrade transcription factor NFATc2, to regulate T-cell activation."
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"Particularly, USP15 promotes the degradation of NFATC2, which negatively regulates T cell activation."
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"Through its deubiquitinase function, USP15 stabilizes MDM2, mediates the ubiquitin-dependent degradation of NFATc2, restrains T-cell viability, and negatively regulates the production of T-cell cytokines [66]."
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