IndraLab

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"Trehalose mediated improvements in motor behaviour were associated with a reduction of the MJD associated neuropathology, as MJD transgenic mice treated with trehalose presented preservation of cerebellar layers thickness and a decrease in the size of ataxin-3 aggregates in Purkinje cells."
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"Trehalose mediated improvements in motor behaviour were associated with a reduction of the MJD associated neuropathology, as MJD transgenic mice treated with trehalose presented preservation of cerebellar layers thickness and a decrease in the size of ataxin-3 aggregates in Purkinje cells."
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"Therefore, at 28weeks of treatment, a footprint analysis was additionally performed to investigate whether trehalose could rescue limb and gait ataxia of MJD transgenic mice."
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"XREF_FIG c a close to significant increase in the stride length (Control = 6.02 +/-0.12 cm, 2% trehalose = 6.51 +/-0.18 cm, p = 0.052, Student 's t test) and a significant decrease in the front base width (Control = 2.01 +/-0.08 cm, 2% trehalose = 1.77 +/-0.07 cm, p = 0.047; Student 's t test) was observed in MJD transgenic females treated with 2% trehalose, revealing that trehalose reduced the gait deficits of MJD transgenic females."
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