IndraLab

Statements

USP1 bound to WDR48 activates homologous recombination. 3 / 3
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"A study in which USP1 -/-, UAF1 -/-/-, and USP1 -/- UAF1 -/-/- double-knockout DT40 cells showed hypersensitivity to camptothecin and an inhibitor of poly (ADP-ribose) polymerase (PARP), which suggests that the USP1 and UAF1 complex promotes HR."
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"Additionally, the same study disrupted the NHEJ pathway, via knockout of Ku70 (also known as XRCC6 or X-Ray repair cross complementing 6), in UAF1 -/-/- cells which restored the cellular resistance to camptothecin and the PARP inhibitor suggesting that the USP1 and UAF1 complex promotes HR, at least in part by suppressing NHEJ."
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"These data altogether suggest that the USP1 and UAF1 complex promotes HR repair via multiple mechanisms : through FANCD2 deubiquitination, as well as by interacting with RAD51AP1.ARTICLE HISTORY Received 15 April 2016 Revised 14 June 2016 Accepted 29 June 2016KEYWORDS deubiquitinating enzyme; homologous recombination repair; RAD51AP1; UAF1; USP1IntroductionDNA double strand breaks (DSBs) are highly lethal LESIONS that must be repaired before cell division ensues."
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