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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Modified UCHL1 increases the amount of glutathione. 2 / 2

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"Quantitative analyses of the ratio of NADPH to NADP + (NADPH and NADP +) and that of GSH to GSSG (GSH and GSSG) revealed that the aberrant overexpression of UCHL1 increased intracellular levels of both NADPH and GSH."

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"In agreement with these results, luciferase assay based quantification experiments also confirmed that overexpression of UCHL1 significantly increased the intracellular levels of both NADPH and GSH in a pentose phosphate pathway dependent manner."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...