IndraLab

Statements

Drug inhibits NLRP3. 6 / 6
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"In clinic settings , drugs directed to inhibit NLRP3 or IL-1beta are now being utilized for numerous autoimmune diseases , however not enough clinical research has supported the use of such treatments in viral infection ."
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"More importantly, an alkaloid drug Colchicine which is known for its effects such as tubulin disruption, alteration of E-selectin distribution on endothelial surfaces, inducing loss of adhesion molecule L-selectins and preventing adhesion and recruitment of neutrophil, has also been shown to inhibit activation of the NLRP3 inflammasome."
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"NLRP3 itself can be inhibited by drugs such as MCC-950 , which has also shown efficacy in models of cardiac ischemia , aortic disease , and other inflammatory conditions ( 53 , 54 ) ."
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"Likewise, a sulfonylurea drug Glyburide which is widely used for the treatment of Diabetes type 2, was also shown to inhibit the NLRP3 inflammasome."
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"These drugs prevent NLRP3 activation by blocking the binding of IL-1 and its receptor , preventing apoptosis and pyroptosis , and reducing induction of the release of other cytokines by the IL-1 pathway to prevent the further development of CRS ."
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"NOD2 stimulation by systemic administration of muramyl dipeptide appears to be beneficial in mouse models of colitis.123 Glyburide (glibenclamide), a sulfonylurea drug for the treatment of type 2 diabetes, is known to inhibit ATP-sensitive K+ channels and thus can prevent NLRP3 inflammasome activation.124 Glyburide has been shown to prevent ventilator-induced lung injury in mice and delay endotoxin-induced lethality in mice, but it has not been applied for animal models of colitis.124, 125PRR signaling has significant roles in intestinal homeostasis, which is mainly composed of the maintenance of commensals."
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