IndraLab

Statements

RELA increases the amount of COPS5. 6 / 6
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"Together with the positive correlation between p65 and CSN5 found in the Cancer Cell Line Encyclopedia (XREF_SUPPLEMENTARY), these results suggested that TNF-alpha-activated p65 transcriptionally upregulates CSN5 expression, which is required for TNF-alpha-mediated PD-L1 stabilization and related functions."
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"Subsequently, p65 activates COP9 signalosome 5 (CSN5) transcription and promotes CSN5 expression."
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"The p65 subunit of NF-κB directly augments the expression of COP9 signalosome complex subunit 5 (CSN5), thereby preventing PD-L1 proteasomal degradation through deebiquitinating it [65] ."
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"The mechanisms involved implies that CCL5 promotes the formation of the kappa-B p65/STAT3 complex, which activates COP9 signalosome 5 (CSN5) transcription, and then CSN5 further regulates the deubiquitination and stability of PD-L1, further inhibiting CD8+ T cell responses and thus leading to immune escape (67)( Figure 1 )."
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"Expression of CSN5 mRNA was induced by TNF simulation and was dependent on the NF-κB subunit RelA/p65, which directly regulated CSN5 expression by binding to its promoter."
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"Expression of CSN5 mRNA was induced by TNF simulation and was dependent on the NF-κB subunit RelA/p65, which directly regulated CSN5 expression by binding to its promoter."
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