IndraLab

Statements

USP10 decreases the amount of USP10. 5 / 5
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"Transfection with the USP10 plasmid resulted in elevated mRNA and protein expression of USP10, while PRDM16 shRNA effectively suppressed USP10 expression (Supplement Fig. 2A–E)."
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"Concordantly, siRNA knockdown of USP10, which caused a down-regulation of USP10 expression by >80%, did not prevent agonist-induced deubiquitination of the GCGR (Fig. S3, C and D)."
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"To exclude the probable off-target effects, two more pairs of USP10 shRNAs were used to knockdown the expression of USP10."
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"As evidenced in Fig. 5B, the overexpression of USP10 upregulated the level of SKP2, and was reduced by USP10 downregulation."
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"41 The results showed that USP10 knockdown promoted AID-Dendra2 signal attenuation (Fig. 1h), while the overexpression of USP10 rather than USP10CA, delayed the attenuation of AID-Dendra2 (Fig. 1i)."
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