IndraLab

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KCNQ2 binds 1A and syntaxin. 2 / 2
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"Here, we demonstrated that syntaxin 1A colocalizes with KCNQ2 subunits at hippocampal presynaptic boutons (XREF_FIG), binds to KCNQ2 in both synaptosomal membranes (XREF_FIG) and oocytes (XREF_FIG), and modulates the function of the homomeric KCNQ2 channels expressed in oocytes (XREF_FIG) by slowing the activation rate ~ 2 fold and decreasing the current amplitudes by about 50%; the latter is not due to reduced total expression or cell surface trafficking and stability of the channels (XREF_FIG)."
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"Interestingly, syntaxin 1A also bound a tandem of helices B+C of KCNQ2 (albeit to a much lesser extent than helix A), although it did not interact with helix B alone."
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