IndraLab

Statements

Alizarin inhibits KCNH2. 3 / 3
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"15 Although the magnitude of increase was small, INaL activation may additively contribute to prolongation of QT interval caused by hERG current inhibition by AZ."
33404133
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"We also found a small but significant increase in INaL, consistent with an earlier report.15 Although the magnitude of increase was small, INaL activation may additively contribute to prolongation of QT interval caused by hERG current inhibition by AZ."
33404133
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"Firstly, HC and AZ induce inhibition of cardiac hERG and IKr (rapid IK) potassium channel, inducing mild QT prolongation, with subsequent risk of ventricular arrhythmia and even cardiac arrest, thus needing QT monitoring."
32405235