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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Sodium atom inhibits SCN5A. 1 / 1

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"When maximal conductance of fast I Na was reduced to 35% of WT model to simulate the SCN5A defect, phase 0 overshoot decreased from +11.4 mV to -8.7 mV, conduction velocity slowed from 61 to 40 cm/sec (66% of WT) and the dome of the right ventricular epicardial action potential was lost (XREF_FIG), consistent with the cellular changes associated with the development of Brugada syndrome."

20025708

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...