IndraLab

Statements

Quercetin inhibits JUN. 7 / 10
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"Western blotting showed that siRNA mediated inhibition of PPAR-gamma transcription led to an increase in AP-1 (c-fos, c-jun) protein expression in H9C2 cells, indicating that quercetin, at least in part, deregulates c-fos and c-jun via the PPAR-gamma signaling pathway."
24039778
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"Additionally, quercetin inhibits the transcriptional activity of NF-κB and activator protein-1 (AP-1), further mitigating inflammation.The aforementioned studies demonstrate that quercetin exhibits broad anti-inflammatory potential by suppressing the expression of various inflammatory mediators and modulating inflammatory signaling pathways."
40260380
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"Suppression of the androgen receptor function by quercetin through protein protein interactions of Sp1, c-Jun, and the androgen receptor in human prostate cancer cells."
20148354
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"Bioflavonoid quercetin inhibits hydrogen peroxide (H2O2)-induced apoptosis via intervention in the activator protein 1 (AP-1)-mediated apoptotic pathway."
10972672
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"Quercetin can stimulate the production of normal peripheral blood mononuclear cell (PBMC) derivatives and can also inhibit COX-2, nuclear factor-κB (NF-κB), activator protein-1 (AP-1), mitogen-activated protein kinase (MAPK), reactive nitric oxide synthase (NOS), and inflammatory C-reactive protein (CRP)."
36619785
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"Quercetin was also suggested to suppress IκB kinase and C-Jun kinase which subsequently could lead to the suppression of NF-κB activation [42,43] ."
27585526
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"XREF_BIBR In a human endothelial cell line ECV304, quercetin treatment downregulated activator protein 1 (AP-1) and ICAM-1 messenger RNA (mRNA) levels, but had no effect on nuclear factor-kappaB (NF-kappaB) activation."
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