IndraLab

Statements

OTUD4 binds USP7-TRAF. 3 / 3
| 3
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"Moreover, while p8 effectively blocked the interaction between OTUD4 and USP7-TRAF, the p8m mutant (S8A) failed to do so (Fig 2F)."
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"Additionally, p2 failed to disrupt the interaction between USP7-TRAF and OTUD4 (S2A Fig)."
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"Specifically, mutation of Asp164 or Trp165 in USP7-TRAF to Alanine significantly reduced OTUD4 binding in GST pull-down assays, confirming that Asp164 and Trp165 are critical for the interaction between OTUD4 and USP7-TRAF (Fig 2E)."
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