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USP22 activates Melanoma. 13 / 13
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"Moreover, we found that USP22 expression is relatively elevated in melanoma when compared with normal skin or tumor‐adjacent normal tissues in Xiangya dataset and two different GSE datasets (GSE15605 and GSE46517) (Figures 1F and S1B)."
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"USP22 promotes melanoma mainly through YAP As a transcriptional activator , YAP exerts its oncogenic functions by promoting the transcription of downstream target genes , such as CTGF and Cyr61 ( 41 ) ."
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"Together, our results demonstrated the upregulation of USP22 in melanoma and its correlation with poor clinical outcomes.2.2 USP22 promotes melanoma metastasis both in vitro and in vivo."
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"These findings suggested that USP22 promotes melanoma metastasis both in vitro and in vivo.2.3 Elevated USP22 induces EMT activation in melanoma."
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"Based on our results, the ferroptosis inhibitor liproxstatin‐1 partially rescued the inhibitory effect of topotecan on metastasis, indicating that pharmacological inhibition of USP22 could partially suppress melanoma metastasis by enhancing ferroptosis sensitivities.Previously, Yi et al. 53 revealed that activating mutations in PI3K or loss of PTEN mediate the ferroptosis resistance of cancer cells."
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"Besides, USP22 was found to augment melanoma and resistance to BRAF inhibitors by stabilizing YAP [34] ."
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"These results demonstrated that USP22 might promotes melanoma metastasis by inducing EMT activation.2.4 USP22 potentiates melanoma metastasis and EMT through activating PI3K/Akt/mTOR pathway."
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"These results suggested that USP22 potentiates melanoma metastasis and EMT through activating the PI3K/Akt/mTOR pathway.2.5 USP22 activates PI3K/Akt/mTOR pathway via SIRT1/PTEN axis."
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"In mechanism, USP22 enhances the stability of STAT1 via deubiquitination and promotes the activation of IFNγ stimulation in melanoma [ 43 ]."
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"In this study, we demonstrate that the ubiquitin-specific peptidase 22 (USP22) is essential for HGF-induced melanoma metastasis."
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"Ablation of USP22 expression remarkably attenuates melanoma migration, invasion, and epithelial-mesenchymal transition in vitro and suppresses melanoma metastasis in vivo."
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"USP22 inhibition, PI3K inhibitor (GDC‐0941), Akt inhibitor (MK‐2206), and mTOR inhibitor (AZD‐8055) strongly inhibited melanoma invasion in melanoma cells (Figure 4F,G)."
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"Herein, we conducted RNA sequencing and found that USP22 promotes melanoma metastasis through the PI3K/Akt pathway."
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