IndraLab

Statements

Domperidone inhibits KCNH2. 6 / 6
2 2 | 2
ctd
No evidence text available
15640612
tas
No evidence text available
15911273
ctd
No evidence text available
28551711
tas
No evidence text available
21185626
reach
"With our model, Domperidone was predicted to block hERG potassium channels and possess a moderately high binding affinity of IC50=0.17μM. Ebastine is a H1 receptor antagonist used in the treatment of allergic rhinitis and chronic idiopathic urticaria."
36599209
reach
"Both domperidone and metoclopramide concentration-dependently blocked HERG currents, and the following values were calculated for IC (50) (the concentrations causing half-maximal inhibition) and n (the Hill coefficient) : 57.0 nmol/l and 0.99 for domperidone, 5.4 micromol/l and 0.95 for metoclopramide."
15640612