IndraLab

Statements

YOD1 increases the amount of Chemokine. 2 / 2
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"As shown in Fig. 4A–F, deletion of YOD1 significantly reduced L18-MDP-induced expression of cytokines and chemokines in macrophages."
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"Given that (i) proinflammatory cytokines cause tissue damage in colitis, (ii) proinflammatory cytokines are predominantly produced by macrophages in DSS-induced colitis, and (iii) ablation of YOD1 increased the expression of proinflammatory cytokines and chemokines in mouse colons upon DSS challenge, it is highly possible that YOD1 influences colitis by regulating macrophages."
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