IndraLab

Statements

Gliotoxin inhibits PSMD14. 3 / 3
| 3
reach
"This assay has demonstrated that gliotoxin and other ETPs inhibit proteasome activity by targeting the essential deubiquitinase Rpn11 in the 19S regulatory complex of the 26S proteasome [111]."
| PMC
reach
"Altogether it is questionable, whether gliotoxin directly inhibits the 20S proteasome or whether the observed inhibition is a secondary effect of for example unspecific protein damage.Only recently, gliotoxin and other ETPs were reported to inhibit Rpn11, a zinc‐dependent deubiquitinating enzyme and an essential component of the 19S regulatory particle of proteasomes responsible for ubiquitin‐mediated protein degradation in cells."
35997236
reach
"However, recent studies using the polyubiquitinated protein substrate Ub GST-Wbp2 (WW domain-binding protein 2, n > 30) to measure 26S proteasome-mediated protein degradation have revealed that gliotoxin and other ETPs inhibit proteasome activity in vitro and in cells by targeting the essential deubiquitinase Rpn11 [30,31] in the 19S regulatory complex of the 26S proteasome [111]."
| PMC