IndraLab

Statements


USP4 inhibits EV71. 3 / 3
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"More recently, Xu et al. demonstrated that upon enterovirus 71 (EV71) infections, USP4 expression was repressed, whereas the overexpression of USP4 suppressed EV71 replication."

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"In this study, we found that enterovirus 71 (EV71) infection attenuated the expression of Ubiquitin specific protease 4 (USP4) in vitro and in vivo, while overexpression of USP4 significantly suppressed EV71 replication."

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"Overexpression of USP4 inhibits EV71 replication by stabilizing TRAF6 to activate NF-kappaB inflammatory signaling."