IndraLab

Statements

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"Genetic silencing of Psmd14 induces ESC differentiation and a decrease in octamer-binding transcription factor 4 (Oct4), which is a master regulator of ESC pluripotency [16]."
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"In addition, the overexpression of Psmd14 and Rpn11 in mESCs antagonized the differentiation and supported the pluripotent state [XREF_BIBR]."
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"To further support this hypothesis we were able to show that Psmd14 overexpression could inhibit differentiation as illustrated in XREF_FIG and XREF_SUPPLEMENTARY."
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