IndraLab

Statements

INSR binds LDLR. 22 / 22
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"Hence, we hypothesize that an interaction between LDLR and IR might occur in HUVECs."
30816192
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"The inter association between LDLR and IR may be a reason to render LDLR functionally inactive in presence of leptin."
25488447
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"It is possible that LDL may stimulate the formation of an IR and LDLR complex and subsequently promotes translocation of the complex from cell membrane to cytosol, ultimately affecting the downstream signaling pathway, including autophagy."
30816192
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"We hypothesise that interactions between IR and LDLR play a role in the atherosclerotic process in subjects with diabetes."
22278734
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"Thus, immunoprecipitation studies were conducted and revealed that LDLR indeed forms a complex with IR in HUVECs."
30816192
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"These results indicate that IR and LDLR probably form a complex and translocate from the cell membrane to the cytoplasm after incubation in LDL."
30816192
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"To further elucidate the relationship between LDL and insulin, interaction between IR and LDLR was explored."
30816192
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"We have earlier shown an inter association between insulin receptor (IR) and LDL receptor (LRLR) showing IR dependent regulation of LDLR activity XREF_BIBR."
25488447
sparser
"These results indicate that IR and LDLR probably form a complex and translocate from the cell membrane to the cytoplasm after incubation in LDL."
30816192
sparser
"In 2012, the IR-LDLR inter-association was identified."
34227185
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"Studies from our laboratory have demonstrated the existence of a co-localized association of IR (insulin receptor) and LDLR (LDL receptor) on the plasma membrane of biological cells xref xref ."
25488447
sparser
"Thus, immunoprecipitation studies were conducted and revealed that LDLR indeed forms a complex with IR in HUVECs."
30816192
reach
"Hence, we hypothesize that an interaction between LDLR and IR might occur in HUVECs."
30816192
sparser
"It is possible that LDL may stimulate the formation of an IR-LDLR complex and subsequently promotes translocation of the complex from cell membrane to cytosol, ultimately affecting the downstream signaling pathway, including autophagy."
30816192
sparser
"A co-immunoprecipitation assay found that LDL receptor (LDLR) and insulin receptor (IR) formed a complex in HUVECs."
30816192
sparser
"This co-association of LDLR with IR and their dissociation by insulin may be an important part of the regulatory mechanism of the normal physiological receptor function in a biological system."
22278734
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"A co-immunoprecipitation assay found that LDL receptor (LDLR) and insulin receptor (IR) formed a complex in HUVECs."
30816192
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"Ramakrishnan demonstrated an intracellular co-association and plasma membrane co-localization of IR and LDLR in HepG2 cells, and insulin stimulation of the cellular expression of LDLR and enhanced its functional activity by disrupting the co-localized IR and LDLR complex 40."
30816192
sparser
"In 2019, the proficiency of signal transmission from this IR-LDLR receptor complex was reported."
34227185
trips
"This co-association of LDLR with IR and their dissociation by insulin may be an important part of the regulatory mechanism of the normal physiological receptor function in a biological system."
22278734
sparser
"To further elucidate the relationship between LDL and insulin, interaction between IR and LDLR was explored."
30816192
reach
"We hypothesise that interactions between IR and LDLR play a role in the atherosclerotic process in subjects with diabetes."
22278734