IndraLab

Statements

CYLD activates AKT. 5 / 7
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"Lim and co-workers showed that CYLD suppresses TGF-beta signalling and prevents lung fibrosis by (indirectly) reducing the stability of Smad3, in an AKT, GSK3beta and E3 ligase carboxy terminus of Hsc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To determine whether CYLD inhibits cell proliferation and survival by suppressing activation of Akt, we performed cell proliferation and apoptosis assays on control and CYLD-knockdown prostate cancer cells treated with or without the PI3K inhibitors LY294002 or wortmannin."
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"Overall, YTHDC2 inhibited cell proliferation and induced apoptosis in PTC cells by regulating CYLD-mediated inactivation of Akt pathway."
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"CYLD decreases Smad3 stability by inhibiting Akt."
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"Together, these data suggest that CYLD decreases Smad3 stability and TGF-beta-signalling by inhibiting Akt."
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