IndraLab

Statements

OTUB1 decreases the amount of YAP1. 2 / 2
| 2
reach
"The ubiquitination assay showed that OTUB1 over-expression could significantly decrease YAP total ubiquitination level and K48-linked ubiquitination, but little effect on K63-linked ubiquitination (Fig. 5L, M)."
36271031
reach
"Adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) mediates YAP phosphorylation and affects cellular energy pressure metabolism [32], while mammalian target of rapamycin complex-2 (mTORC2) directly phosphorylates YAP (Ser 463), enhancing YAP activity and promoting the malignant phenotype of glioblastoma [33]; the deubiquitinase OTUB1 reduces YAP ubiquitination levels and inhibits YAP degradation, thereby promoting the proliferation activity of gastric cancer cells [34]."
40312366