IndraLab

Statements

USP7 activates AR. 4 / 4
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"For example, USP7 modulates androgen receptor transcriptional output by restraining the binging of androgen receptor to chromatin ( Chen et al., 2015 )."
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"USP7 overexpression resulted in reduced ubiquitination and enhanced AR aggregation in vitro (Pluciennik et al., 2021)."
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"Anna Pluciennik et al. discovered that the deubiquitinase USP7 selectively interacts with polyQ-expanded androgen receptor (AR) in spinal and bulbar muscular atrophy (SBMA) and that decreasing usP7 levels reduced mutant AR aggregation and cytotoxicity in cell models of SBMA, suppressed disease phenotypes in SBMA and spinocerebellar ataxia type 3 (SCA3) fly models, and improved several motor deficiencies in transgenic SBMA mice, highlighting the critical role of USP7 in the pathophysiology of SBMA and suggesting a similar role in SCA3 and HD [82]."
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"In prostate cancer, HAUSP deubiquitinates and rescues androgen receptor (AR) upon androgen stimulation and subsequently upregulates AR responsive gene expression by direct association with AR on chromatin."
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