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USP8 deubiquitinates BACE1 on K501. 2 / 2

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"USP8 acts on the trafficking and degradation of BACE1 through deubiquitinating K501 of the BACE1 ( Yeates and Tesco, 2016 )."

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signor

"Accordingly, we reported that BACE1 is ubiquitinated at lysine 501 and that lack of ubiquitination at lysine 501 produces BACE1 stabilization.Our findings demonstrate that USP8 plays a key role in the trafficking and degradation of BACE1 by deubiquitinating lysine 501."

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USP8 deubiquitinates BACE1 on K501. 2 / 2

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