IndraLab

Statements

OTUD3 activates IFNB1. 2 / 2
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reach
"Additionally, we confirmed that the enhancement of OTUD3 on cGAS/STING-induced IFN-β promoter luciferase reporter activity depended on its enzyme activity ( Figure S10 F)."
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"OTUD3 depletion by shRNA obviously potentiated the SeV-induced activity of the Ifnb1 promoter and the positive regulatory domain (PRD) I–III reporter, which contained an IRF3-binding site ( Figures S1[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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