IndraLab

Statements


HGF inhibits KCNH2. 2 / 2
| 2

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"Therefore another goal of this work was to investigate the role of the SF in the drug induced blockade of hERG leading to ALQTS."

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"The gain-of-function mutation N629D at the outer mouth of the selectivity filter (SF) disrupts inactivation and K + -selective transport in hERG1, leading to arrhythmogenic phenotypes associated with long-QT syndrome."