IndraLab

Statements

HCN4 decreases the amount of GCGR. 2 / 2
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"Despite co-localization of HCN4 and GLP-1R in primate hearts, HCN4 directed Cre expression did not attenuate levels of Glp1r mRNA transcripts, but did reduce atrial Gcgr expression in the mouse heart."
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"As the structurally related glucagon receptor (Gcgr) has been localized to the mouse SAN XREF_BIBR and like GLP-1, transduces an acute increase in HR XREF_BIBR, we examined whether Hcn4 Cre mice would enable reduction of atrial Gcgr expression."
29107282