IndraLab

Statements

KCNMA1 binds NPHS1. 5 / 7
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"The Slo1-nephrin interaction was confirmed by coimmunoprecipitation from the brain and kidney, from HEK-293T cells expressing both proteins, and by glutathione S-transferase pull-down assays."
18480178
sparser
"We detected nephrin binding to the Slo1 VEDEC splice variant, which is typically retained in intracellular stores, and to the beta4-subunit."
18480178
sparser
"However, we did not detect significant binding of nephrin to the Slo1 QEERL or Slo1 EMVYR splice variants."
18480178
sparser
"Stimulation of Slo1 VEDEC surface expression in HEK-293T cells was also observed by coexpressing a small construct encoding only the distal COOH-terminal domains of nephrin that interact with Slo1."
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reach
"Since nephrin binds and regulates BK channel expression, any change in nephrin protein level, such as those documented here by ouabain, may affect BK channel expression and consequently the GFR."
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