IndraLab

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NPHS1 binds KCNMA1. 6 / 8
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"The Slo1-nephrin interaction was confirmed by coimmunoprecipitation from the brain and kidney, from HEK-293T cells expressing both proteins, and by glutathione S-transferase pull-down assays."
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"We detected nephrin binding to the Slo1 VEDEC splice variant, which is typically retained in intracellular stores, and to the beta4-subunit."
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"However, we did not detect significant binding of nephrin to the Slo1 QEERL or Slo1 EMVYR splice variants."
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"Stimulation of Slo1 VEDEC surface expression in HEK-293T cells was also observed by coexpressing a small construct encoding only the distal COOH-terminal domains of nephrin that interact with Slo1."
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"Since nephrin binds and regulates BK channel expression, any change in nephrin protein level, such as those documented here by ouabain, may affect BK channel expression and consequently the GFR."
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"It has been shown that nephrin can interact with the Slo1 and β4 subunits of BK Ca channels, and that nephrin and actin dynamics are necessary for the normal expression of functional BK Ca channels on[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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