IndraLab

Statements

PSMD14 activates GRB2. 7 / 7
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"Additionally, PSMD14 can accelerate hepatocellular carcinoma development and metastasis by stabilizing GRB2 [22]."
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"PSMD14 is known to enhance HCC progression and metastasis by stabilizing GRB2 [41]."
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"Herein, we evaluated the therapeutic effects of OPA in malignant phenotypes of HCC cells and found that it could significantly inhibit HCC growth and metastasis in vitro and in vivo , indicating that [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"PSMD14 could inhibit GRB2 degradation by deubiquitinating this oncoprotein in liver cancer cells (Lv et al., 2020)."
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"Considering that GRB2 played a critical role in enhancing the malignant behavior of cancer cells [ 13 ], and the ubiquitination of GRB2 remains elusive, we revealed the mechanism underlying PSMD14-med[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The decrease K48-linked ubiquitination on GRB2 induced by PSMD14 increases the stability of GRB2, leading to an increase in GRB2 protein levels and promoting the progression of hepatocellular carcinoma (31)."
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"Furthermore, we observed that PSMD14 promoted proliferation, migration, and invasion in vitro and tumor growth metastasis in vivo by stabilizing GRB2 protein."
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