IndraLab

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COPS6 increases the amount of CDKN2A. 3 / 3
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"Moreover, the expression trends of CSN6 and p16 in CSN6-treated tumor groups were consistent with the results of in vitro studies, which demonstrated that CSN6 promoted cancer cell growth by reducing p16 expression."
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"Thus, we performed ubiquitination assay and found that CSN6 overexpression did not increase the endogenous ubiquitination level of p16 (Figure 5A)."
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"Additionally, our data demonstrated that CSN6 promoted proliferation of GC by inhibiting the expression of p16 via an ubiquitination-independent degradation pathway."
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