IndraLab

Statements

CYLD inhibits Death. 3 / 4
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"CYLD recognises and cleaves K63-linked ubiquitin chains to promote protein–protein interactions in the assembly of signalling molecule complex.32 CYLD can inhibit NF-κB upstream signalling molecules and regulate inflammatory response by deconjugating the K63-linked ubiquitin chains.33 Disruption of CYLD induces hepatocyte death and activates Kupffer cells, which promotes inflammation and pro-inflammatory mediators,34 suggesting that CYLD is an essential regulator of immune and inflammatory responses."
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"CYLD deficiency triggers a multistep mechanism that mimics the major hallmarks of human HCC: hepatocyte death, inflammation, and fibrosis."
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"Therefore, lack of CYLD catalytic activity inhibited the p53 dependent death of IECs in response to DNA damage in vivo and in vitro."
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