IndraLab

Statements

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"Moreover, downregulation of CIB1 impaired USP14-mediated cell proliferation in PLC-C and Huh7-C cells (Fig. 5c-d)."
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"Downregulation of USP14 Suppresses the Proliferation of ESCC Cells."
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"The results demonstrated that downregulation of USP14 significantly inhibited the proliferation in EC109 (XREF_FIG) and TE10 cells (XREF_FIG)."
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"We found that sh-USP14 significantly inhibits the proliferation, invasion, and invasion of liver cancer cells, promoting apoptosis."
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"Similarly, the CCK-8 assay revealed that sh-USP14 significantly suppressed the proliferation of MHCC97H and HCCLM3 cells compared to that in the NC group (Fig. 2D)."
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"Loss of USP14 slows cell proliferation and alters the actin cytoskeleton."
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"Downregulation of USP14 may suppress cell proliferation, migration, and promote cell apoptosis via stabilizing AR in prostate cancer or AR-positive BCa (16, 25)."
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"We also found that downregulation of USP14 significantly inhibited ESCC cell proliferation and ESCC tumor growth in nude mice."
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"Medicated serum of TY (1.05, 2.1, and 4.2 g/kg) dose‐dependently and TGT inhibited the proliferation of HFLS‐RA cells, compared with TNF‐α group (p < .01) (Figure 5A)."
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"These results suggested that sh-USP14 inhibited the proliferation, invasion, and migration of MHCC97H and HCCLM3 cells via HK2."
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"Concomitant ablation of USP14 and UCHL5 strongly inhibits cell proliferation."
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"Pharmacologic inhibition of USP14 with IU1 enhances ubiquitin turnover without inhibiting cell proliferation."
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"The results proved that downregulation of USP14 significantly inhibited the proliferation and migration in PDGF-BB-induced HASMCs (Fig. 3B and C)."
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"Furthermore, this study explored the mechanism of USP14 inhibition of liver cancer proliferation and invasion by examining its effect on the AKT and EMT signaling pathways."
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"Ubiquitin-specific peptidase 14 (USP14) knockdown can increase the ubiquitination of cyclin B1 and promote its degradation, causing cell cycle arrest in the G2/M phase, thus inhibiting the proliferati[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Knockdown of Ubiquitin Specific Protease 14 (USP14) Inhibits the Proliferation and Tumorigenesis in Esophageal Squamous Cell Carcinoma Cells."
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"Downregulation of USP14 significantly inhibited ESCC cell proliferation and ESCC tumor growth in nude mice."
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"In addition, the H&E staining results showed that TGT and Mat significantly reduced synovial tissue proliferation, inflammatory cell infiltration, cartilage erosion, bone destruction, and formation of[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"For example, Zhu et al. reported that expression of USP14 was increased in breast cancer tissues, and downregulation of USP14 significantly inhibited breast cancer cell proliferation and metastasis XREF_BIBR."
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"40 , 41 USP14 inhibits apoptosis by inhibiting the bcl‐XL signaling pathway and promotes proliferation by stimulating the Wnt signaling pathway in multiple myeloma."
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"Liu et al. reported that USP14 loss inhibits PDGF-BB-induced phenotypic modulation, migration, and proliferation [31]."
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"Clone formation and EdU assays verified that USP14 loss induces cell proliferation with or without PDGF-BB treatment."
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"TGT inhibited osteosarcoma cell proliferation in vitro."
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"USP14 interference impeded MCL cell proliferation."
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"We found that (i) USP14 could bind to AR, and additionally, both genetic and pharmacological inhibition of USP14 accelerated the ubiquitination and degradation of AR; (ii) downregulation or inhibition of USP14 suppressed cell proliferation and colony formation of LNcap cells and, conversely, overexpression of USP14 promoted the proliferation; and (iii) reduction or inhibition of USP14 induced G0/G1 phase arrest in LNcap prostate cancer cells."
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"It was also reported that the direct targeting of USP14 and vimentin by miR-320a inhibited GC cell proliferation, migration and invasion."
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"USP14 ablation reduces cancer cell proliferation in vitro and colorectal tumorigenesis in vivo by downregulating MAPK/JNK pathway activation."
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"TGT was shown to dramatically suppress the proliferation, migration and invasion, and induce apoptosis of osteosarcoma 143B and MG-63 cells in vitro."
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"Knockdown of USP14 with the lentiviral vector delivery of shRNA in human hepatocarcinoma SMMC7721 cells suppressed cell proliferation, altered the cell cycle and induced cell apoptosis."
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"The KD of USP14 markedly impeded the proliferation and sphere-forming capacity of GSC cells in vitro (Figure 2B-C and S2A-B)."
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"Finally, we found that USP14 depletion- and DGS/X-ray therapy-mediated proliferation, EMT process and DNA damage biological processes were almost abolished upon YAP1 overexpression, uncovering that YAP1 blockage was required for DGS/X-ray therapy to depress the malignant biological behaviors of ESCA cells through USP14 signal."
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"In this study, USP14 promoted the G1-S phase transition of Hela and Siha cells and inhibited cell apoptosis, thereby promoting the proliferation, migration, and invasion of CC cells."
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"The KD of USP14 resulted in elevated global levels of m A (Figure 6E) and inhibited both the proliferation and sphere-forming capacity of GSCs in vitro (Figure 6F-G)."
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"The downregulation of USP14 significantly inhibited breast cancer cell proliferation and metastasis."
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"Functional experiments showed that si-USP14 offset OGD/R treatment-induced suppression of cell proliferation and enhancement of apoptosis rate [Figure 2b-d]."
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