IndraLab

Statements

Isobutanol inhibits KCNK18. 3 / 3
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"In addition, the sanshool derivative IBA, which blocked TRESK currents in transfected HEK293 cells and DRGs, increased intracellular calcium in 49% of DRG neurons in culture."
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"Lamotrigine, a Na channel blocker, and IBA, an alkylamide derivative of hydroxyl-α-sanshool, inhibit TRESK currents with an IC of 47 μM and ~500 μM, respectively [32,43]."
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"In another study rather high concentration (100 and 500 muM) of isobutylalkenyl amide (IBA) was found to inhibit TRESK."
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