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OTUD3 activates glucose. 4 / 4
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"Our previous study indicated that OTUD3 promoted lung tumorigenesis through stabilizing the glucose-regulated protein 78 kDa (GRP78) [2, 17]."
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"However, nuclear endogenous OTUD3 levels increased with FFA ( Figure 6 A, lanes 8–12 versus lane 7) or glucose ( Figure S7 A, lanes 9–11 versus lanes 7 and 8) stimulation in a dose-dependent manner in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Nuclear OTUD3, in turn, promotes glucose and fatty acid metabolism through stabilized diverse energy-metabolism-related transcription factors."
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"Remarkably, OTUD3 promotes lung tumorigenesis by stabilizing the glucose-regulated protein 78 kDa (GRP78) [26], which is a multifunctional protein with activities far beyond its well-known role in controlling unfolded protein response and implicated in promoting tumor proliferation, metastasis and involved in drug resistance [30–36]."
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