IndraLab

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ATG7 activates USP28. 3 / 3
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"To investigate the mechanisms of ATG7 upregulating USP28 protein, we first examined usp28 mRNA levels in ATG7 knockdown transfectants."
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"The results showed that knockdown of ATG7 decreased human usp28 promoter driven reporter transcription activity (XREF_FIG), revealing that ATG7 promotes usp28 promoter transcription."
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"Mechanistically, ATG7 upregulates the deubiquitinase USP28, which removes the ubiquitin group from CD44 protein leading to stabilization of CD44 protein to control stem-like proprieties in bladder can[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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