IndraLab

Statements

USP21 deubiquitinates PLK1. 5 / 5
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"Here, we further show that O-GlcNAcylation of USP16, the DUB of PLK1, enhances PLK1 deubiquitination, ensuring correct mitotic progression."
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"Nuclear USP16 also deubiquitinates PLK1 for mitotic chromosome alignment and c-Myc in prostate cancer [45,46]."
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"Ubiquitin-specific peptidase 16 (Usp16) antagonizes the activity of CUL-3-based ubiquitin ligase by deubiquitinating PLK1 at the kinetochore [94]."
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"USP16 deubiquitinates PLK1, increasing PLK1-kinetochore association to ensure proper chromosome alignment during early mitosis (28)."
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"USP16 O-GlcNAcylation promotes H2A and PLK1 deubiquitination in cells."
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