IndraLab

Statements

USP4 activates Fibrosis. 3 / 3
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"LncRNA H19 180 acts as a ceRNA to downregulate the expression of miR-148a and upregulate the expression of USP4, which stabilizes the TGFβRⅠ and activates the TGF-β/smad signaling pathway and promotes the development of liver fibrosis."
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"In a model of autoimmune hepatitis in mice, the expression of USP4 was found to be reduced upon treatment with Vi-A, thereby reducing inflammation and fibrosis in the liver [31]."
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"The intervention using Vialinin A and liver X receptor α (LXRα)-induced cannabinoid receptor 2 (CB2) has been found to reduce the level of USP4, leading to alleviate inflammation and fibrosis in the liver (74)."
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