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Modified USP4 leads to the dephosphorylation of IKK_complex. 2 / 2
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"Furthermore, we found that overexpression of USP4 wild-type inhibited TAK1 and TAB1 co-overexpression-induced TAK1, IKK and MAPK phosphorylation in HEK293T cells whereas TAK1 C311A mutant and CYLD had no any inhibitory effect (XREF_SUPPLEMENTARY)."
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"Furthermore, it was found that overexpression of USP4 can inhibit interleukin-1 beta (IL-1beta), lipopolysaccharide (LPS), and TGF-beta-induced NF-kappaB-dependent luciferase reporter activity and Ika[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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