IndraLab

Statements


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"Butorphanol Suppression of Histamine Itch is Mediated by Nucleus Accumbens and Septal Nuclei."

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"We found that i.t. injection of butorphanol (2 nmol) significantly reduced CQ induced scratching behaviors in WT, but not in Oprk1 -/- mice (XREF_SUPPLEMENTARY), suggesting that butorphanol inhibits CQ itch via a KOR dependent mechanism."

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"Administered intranasally at doses ranging from 1 to 4 mg daily, butorphanol has reduced itch and improved sleep in the setting of prurigo nodularis, primary biliary cirrhosis, and lymphoma."