IndraLab

Statements

11,12-EET activates KCNMA1. 6 / 6
| 6
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"Two lines of evidence suggest that CYP epoxygenase plays an important role in mediating the effect of high K intake on K secretion in the CCD [XREF_BIBR] : (1) high K intake increased epoxyeicosatrienoic acid (EET) levels in the CCD and (2) 11,12-EET stimulates BK channel activity in the CCD."
18839206
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"11,12-EET stimulates the association of BK channel alpha and beta (1) subunits in mitochondria to induce pulmonary vasoconstriction."
23029390
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"Application of both arachidonic and 11,12-EET increased BK channel activity, even when CYP-epoxygenase was inhibited."
25589264
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"Thus, although a decrease in 11,12-EET generation is expected to diminish the BK channel activity, K secretion in Cyp2c44 (-/-) mice is normal through increasing ROMK channel activity and enhanced driving force for K secretion."
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"Correction : 11,12-EET Stimulates the Association of BK Channel alpha and beta 1 Subunits in Mitochondria to Induce Pulmonary Vasoconstriction."
| PMC
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"From these data we conclude that 11,12-EET does not activate the classical NS1619 sensitive BK channel population at the plasma membrane."
23029390