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USP7 activates USP7. 4 / 6
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"First of all , we generated mouse anti-Usp7 antibody and found that knockdown of usp7 apparently decreased Usp7 signals , whereas overexpression of usp7 elevated Usp7 signals ( Figs ."
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"Taken together, these results suggested that ECT2 counteracts the polyubiquitination of USP7 thus promotes USP7 stabilization in a GEF activity independent manner."
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"Furthermore, we revealed that ECT2 depletion impaired the upregulation of endogenous USP7 induced by forced expression of GFP-USP7."
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"The TME includes adipocytes [3, 134], and one study showed that the exo-circ-deubiquitination (exo-circ-DB) derived from adipocytes upregulated the expression levels of USP7 and Cyclin A2 by sponging miR-34a and activating the USP7/CyclinA2 signalling pathway, thereby promoting the tumorigenesis and metastasis of HCC [135]."
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