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USP7 activates USP7. 12 / 14
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"Taken together, these results suggested that ECT2 counteracts the polyubiquitination of USP7 thus promotes USP7 stabilization in a GEF activity independent manner."
32929379
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"While the relationship between USP7 and EZH2 and its significance in NB pathogenesis have not yet been established, our results have shown direct correlations between USP7 downregulation induced by inhibition of its deubiquitinase activity via Almac4 or by USP7 depletion and EZH2 and N-Myc ubiquitination and protein degradation."
37762082
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"Furthermore, we revealed that ECT2 depletion impaired the upregulation of endogenous USP7 induced by forced expression of GFP-USP7."
32929379
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"The TME includes adipocytes [3, 134], and one study showed that the exo-circ-deubiquitination (exo-circ-DB) derived from adipocytes upregulated the expression levels of USP7 and Cyclin A2 by sponging miR-34a and activating the USP7/CyclinA2 signalling pathway, thereby promoting the tumorigenesis and metastasis of HCC [135]."
31973726
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"Our data revealed that USP7 protein expression was significantly upregulated in PTC tissues.To explore the underlying role of USP7 in regulating PTC progression, we performed qRT-PCR and Western blott[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32966862
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"IHC showed that expression levels of both USP7 and PD-L1 in the cancer tissues were significantly higher than those in the normal tissues (online supplemental figure S9), and USP7 levels were positively correlated with PD-L1 levels in cancer tissues(figure 7A, B), supporting USP7 as the deubiquitinase of PD-L1."
37001908
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"These results indicated that ATF4 might directly regulate USP7 expression.To assess whether ATF4 can directly regulated Usp7 promoter activity, we analyzed the promoter region of Usp7 and found a cAMP[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27452504
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"FTO promoted the expression of USP7 by demethylating its mRNA and increasing the stability of USP7 mRNA.In conclusion, our findings demonstrate that the FTO-USP7 axis is critically involved in human N[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30905413
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"These results indicate that USP7 lowly expresses in SCI and USP7 overexpression promotes HMOX-1 expression through deubiquitination.To ascertain the impact of USP7 in SCI, the assessment of BBB motor [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37257587
eidos
"First of all , we generated mouse anti-Usp7 antibody and found that knockdown of usp7 apparently decreased Usp7 signals , whereas overexpression of usp7 elevated Usp7 signals ( Figs ."
30679505
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"The expression of USP7, RXRA, and BECN1 was highly elevated in pancreas cells, with USP7 and RXRA significantly upregulated in most cell clusters of T2D samples."
39130628
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"While we have established that the two closely related proteins, Hdm2 and HdmX, have a conserved USP7 interaction site, the functional significance of this conserved interaction site is still unknown [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20713061