IndraLab

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ERG28 activates KCNMA1. 4 / 4
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"ERG-28 promotes SLO-1 trafficking to the plasma membrane."
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"Loss of erg-28 suppressed phenotypic defects of slo-1 gain-of-function mutants in locomotion, neurotransmitter release, and calcium mediated asymmetric differentiation of the AWC olfactory neuron pair, and conferred significant ethanol resistant locomotory behavior, resembling slo-1 loss-of-function mutants, albeit to a lesser extent."
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"We tested whether neuronal expression of erg-28 restores the sluggish movement of slo-1 (ky399gf) by expressing GFP tagged ERG-28 in erg-28 (cim16) slo-1 (ky399gf) double mutants under the control of the pan-neuronal H20 promoter or muscle specific myo-3 promoter."
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"Taken together, we conclude that ERG-28 promotes SLO-1 channel trafficking to the plasma membrane by shielding SLO-1 channels from proteasomal degradation."
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