IndraLab

Statements

KCNQ1 increases the amount of Kcnq1ot1. 3 / 3
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"This result coincided with the up-regulated transcription of KCNQ1 in the spinal cord of human NTDs (XREF_FIG), because hypermethylated KvDMR1 is known to inhibit the expression of the lncRNA Kcnq1ot1 gene, and loss function of Kcnq1ot1 consequently promotes KCNQ1 transcription (XREF_FIG) XREF_BIBR."
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"However, Kcnq1ot1 regulates Kcnq1 transcription, not by regulating its imprinting, but through modulating chromatin flexibility and access to enhancers [XREF_BIBR]."
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"Kcnq1ot1, a new lncRNA regulates Kcnq1 transcription through modulating chromatin flexibility and access of transcriptional machinery to its enhancer [XREF_BIBR]."
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