IndraLab

Statements

Histone inhibits NLRP3. 3 / 3
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"Recent work has elucidated an array of signaling functions of BHB : inhibitor of the NLRP3 inflammasome, inhibitor of histone deacetylases, ligand of G protein coupled receptors, and a covalent histone modification associated with fasting activated genes."
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"NLRP3 Inflammasome Inhibition by Histone Acetylation Ameliorates Sevoflurane induced Cognitive Impairment in Aged Mice by Activating the Autophagy Pathway."
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"This inhibition is mediated not only through reduction of the release of extracellular histones in the lung but also through direct blockage of extracellular histone induced activation of the NLRP3 inflammasome."
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